Christina Applegate.

Christina Applegatehas received an Emmy nomination for her role in the final season ofDead to Me, which she filmed amid hermultiple sclerosisdiagnosis.
The 52-year-old portrayed Jen Harding in the Netflix series and snagged her third nomination for Outstanding Actress in a Comedy Series on Wednesday ahead of the 75th annual awards ceremony in September.
Applegate — was diagnosed with MS in August 2021, while she was filmingDead to Me’s third and final season.
Multiple sclerosisis a disease that affects the central nervous system — the brain and spinal cord — and can cause problems with muscle control and strength, vision, balance, feeling and thinking. Symptoms include: numbness, tremor or lack of coordination.
MS differs in each case, with some people going through life with only minor problems and others becoming seriously disabled.
Christina Applegate and Linda Cardellini in Dead to Me.Saeed Adyani/Netflix

After her diagnosis,Dead to Mepaused production so Applegate could begin treatment. When the series eventually wrapped, the actress spoke toVarietyin November 2022 about the future of her career, revealing that finishing the show with her symptoms was “as hard as you would possibly think it would be.”
She went on to explain that she’s seeking “a place that will allow me to [work five hours] if I’m not the star,” and that starring in something might be off the table in the future. “There’s no way I could do the work that I just came off again. I mean, it wassohard,” she said.
Christina Applegate.Stewart Cook/Shutterstock

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During a May interview withVanity Fair, theMarried with Childrenalum suggested that a chapter in her decades-long acting career has likely come to an end, explaining that she has no plans to return to the screen.
“I’m probably not going to work on-camera again,” Applegate said while praising the experience of working with Linda Cardellini onDead to Me.
“I can’t even imagine going to set right now,” she added. “This is a progressive disease. I don’t know if I’m going to get worse. I can do voiceover stuff because I have to support my family and keep my brain working.”
Throughout her career, Applegate has earned seven Emmy nominations — three forDead to Me, two forSamantha Who?, and one forFriends, where her performance earned her the Emmy award for Outstanding Guest Actress in a Comedy Series in 2003.
The 75th Emmy Awards are currently scheduled to be broadcast live Sept. 18 at 8 p.m. ET/5 p.m. PT on Fox.
source: people.com